{"schema_version":"twog-public-evidence-bundle-v1","candidate_id":"rly2608-pik3ca","title":"RLY-2608 (mutant-selective allosteric PI3Ka) × PIK3CA","public_status":"evidence_supported","snapshot":{"snapshot_id":null,"content_hash":"517e8ac311b96f9db32cd2445ce792f94bd973ff","snapshot_version":null,"pipeline_version":null,"generated_at":null},"run_manifest":{"trace_id":null,"run_manifest_id":null,"dagster_run_id":null,"commit_sha":null,"compute_job_ids":[],"decision_count":0,"run_manifest_found":false,"record":null,"note":"This is the pipeline receipt for the public candidate snapshot. If trace_id, run_manifest_id, or record is null, the static export is not audit-ready and should be refreshed from Neon."},"checkout":{"candidate_payload_url":"/api/public-candidates/rly2608-pik3ca","evidence_bundle_url":"/api/public-candidates/rly2608-pik3ca/evidence-bundle","contribution_template_url":"/api/public-candidates/rly2608-pik3ca/contribution-template","contribution_submission_url":"/api/public-candidates/rly2608-pik3ca/contributions","intended_use":"Use this bundle to inspect the record, cite source refs, reproduce public claims, attach outside evidence, or submit validation/compute work back to TWOG intake."},"claim_packet":{"rationale":{},"biology":{},"evidence":{},"linked_records":{}},"source_documents":[],"chunk_manifest":[],"artifact_manifest":{"artifacts":[],"note":"Artifacts are listed when the candidate has public-safe files such as poses, plots, notebooks, trajectories, or method outputs."},"compute_manifest":{"status":"no_public_compute_runs_yet","compute_job_ids":[],"computational_evidence":[],"md_reproducibility_contract":{"purpose":"When docking or MD evidence is attached, this is the minimum public shape needed for another reviewer to rerun or critique the job.","required_inputs":["protein_pdb or protein_pdb_artifact_url","compound_smiles or ligand_structure_artifact_url","target_name","compound_name","protein_source","ligand_source","preparation_method"],"required_settings":["simulation_steps","temperature","ph","box_padding","force_field","solvent_model","seeds","container_image","modal_endpoint_or_worker"],"expected_artifacts":["sanitized_protein_pdb","ligand_sdf_or_mol","receptor_pdbqt","ligand_pdbqt","pose_or_initial_complex","trajectory_or_smoke_output","stage_diagnostics","stdout_stderr_tails","artifact_hashes"],"gate":"Public submissions can request docking_or_md_review, but GPU work remains approval-first and ledgered inside TWOG."}},"contribution_packet_requirements":{"accepted_types":["evidence","critique","replication","artifact","validation_proposal","compute_result"],"compute_result_minimum_fields":["method_or_tool","input_snapshot_content_hash","input_files_or_urls","settings","container_or_software_versions","outputs","artifact_hashes","limitations"]}}