SURVIVEDcapivasertib akt1

Capivasertib → AKT1 (PI3Kα→AKT1 axis node)

What we’re testing

target · AKT1

Mechanism. Capivasertib (AZD5363, approved) is an ATP-competitive AKT inhibitor. AKT1 is the surviving synthetic-lethal co-dependency of PIK3CA-mutant cells (DepMap 24Q4) — the node downstream of the driver. This docking test scores pocket engagement on the verified AKT1 receptor; an approved AKT inhibitor binding AKT1 is expected — the value is establishing the dockable PI3Ka->AKT1 axis node for future novel-modality bets, not a surprising result.

Where it stands — still standing

Survived every test the engine could run. Nothing here is proven — that's the point.

Status on the engine: evidence supported · validation-ready. Nothing here is promoted automatically — a human holds the final call.

Follow the trail

See the evidence →1 test

the pre-registered tests, verdict, and signed provenance

View the run →

the campaign that tested this idea — Falsification campaign — 5 candidate(s), runner=modal

Grounded in

DepMap:24Q4 AKT1 co-dependency of PIK3CA-mutPDB:4GV1target_library:AKT1 (redock 1.829A)

How we know it’s real

content-addressed · d9806fc571d71145…updated 2026-07-13

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