Versioned methodology

The rulebook.

TWOG separates each public record from the method used to create it — the public rulebook for candidate pages, evidence bundles, contribution intake, compute smoke tests, citation repair, and omics readouts.

7
versioned methods
3
hard boundaries
0
medical claims certified
Autonomous Discovery Loop v2.2v2.2 · discovery orchestration

How TWOG drives its own scientific crux: it proposes the next falsifying test, pre-registers a hashed kill-criterion before compute, resolves its own inputs, dispatches real GPU work, and audits the result through confound and provenance gates before deciding what to test next.

activefalsification attempt5 sectionscandidate cruxes
Candidate Record v1v1 · public proof layer

How TWOG converts internal research artifacts into stable public candidate pages with rationale, evidence, risks, decision history, and reproducibility metadata.

activeresearch artifact5 sectionscandidate pages
Evidence Bundle v1v1 · checkout packet

What TWOG includes when someone checks out a candidate for outside review: source records, chunk provenance, artifact manifests, compute settings, and contribution routes.

activesource dossier4 sectionspublic payloads
Contribution Intake v1v1 · public check-in

How outside evidence, critiques, replication notes, artifacts, and validation proposals are checked back into TWOG without directly mutating public candidate records.

pausedqueued contribution4 sectionsoutside submissions
MD Smoke v1v1 · compute gate

The first molecular-dynamics compute contract for TWOG: expert-reviewed inputs, small smoke settings, structured worker diagnostics, and ledgered artifacts.

operator-gatedworkflow proof4 sectionsModal MD smoke jobs
Citation Dedupe v1v1 · evidence hygiene

How TWOG collapses duplicate citation refs, preserves merged provenance, and prevents repeated chunks from masquerading as independent evidence.

activeprovenance repair4 sectionsbriefs and candidate references
Omics Readout v1v1 · processed omics

The processed-first omics method for scoring target expression and gene-set signals from public matrices before any raw FASTQ/BAM reprocessing.

active internaldescriptive signal4 sectionsprocessed expression matrices