RUNNINGcnx1351 × PIK3CA

CNX-1351 (covalent PI3Ka, Cys862) × PIK3CA

What we’re testing

target · PIK3CAPIK3CA

Mechanism. Covalent isoform-selective inhibition of PI3Ka at Cys862.

Where it stands — needs more testing

Tested as far as its inputs allowed — no verdict yet.

Status on the engine: needs more testing · validation-ready. Nothing here is promoted automatically — a human holds the final call.

Follow the trail

See the evidence →1 test

the pre-registered tests, verdict, and signed provenance

View the run →

the campaign that tested this idea — Falsification campaign — 45 candidate(s), runner=modal

Grounded in

pubchem:58441401Nacht et al. Chem Biol 2013 — CNX-1351 covalent PI3Ka (Cys862)

How we know it’s real

content-addressed · 29527aa69e808453…updated 2026-07-07

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Contribute to this idea

Have evidence, a critique, a replication, or compute to add? When contributor check-in is open you can submit a bounded packet — queued for human review, and it never changes the record on its own.

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