SURVIVEDcopanlisib pik3ca canine

Copanlisib warhead → canine PIK3CA (PROTAC warhead)

What we’re testing

target · PIK3CA_CANINE

Mechanism. Copanlisib (BAY 80-6946) is the PI3Kα-binding POI WARHEAD of the best-validated PI3Kα PROTAC degrader D5 (DC50 0.05 nM); ATP-competitive orthosteric. This docking test scores POCKET ENGAGEMENT only — not degradation (which needs ternary-complex / E3 modeling) and not mutant-selectivity (the canine receptor is wild-type). A good pose is a necessary first step, not proof of a working degrader.

Where it stands — still standing

Survived every test the engine could run. Nothing here is proven — that's the point.

Status on the engine: evidence supported · validation-ready. Nothing here is promoted automatically — a human holds the final call.

Follow the trail

See the evidence →1 test

the pre-registered tests, verdict, and signed provenance

View the run →

the campaign that tested this idea — Falsification campaign — 5 candidate(s), runner=modal

Grounded in

PMID:41796700target_library:PIK3CA_CANINE (redock 0.624A)

How we know it’s real

content-addressed · dc67a7863dead017…updated 2026-07-13

Every idea and every result is hashed so anyone can re-derive it. Want a drug or target put to the test? Suggest one →

Contribute to this idea

Have evidence, a critique, a replication, or compute to add? When contributor check-in is open you can submit a bounded packet — queued for human review, and it never changes the record on its own.

Checking whether check-in is open…