RUNNINGrly2608 × PIK3CA

RLY-2608 (mutant-selective allosteric PI3Ka) × PIK3CA

What we’re testing

target · PIK3CAPIK3CA H1047RPIK3CA E545K

Mechanism. Mutant-selective allosteric inhibition of PI3Ka (H1047R/E545K), sparing wild-type.

Where it stands — needs more testing

Tested as far as its inputs allowed — no verdict yet.

Status on the engine: needs more testing · validation-ready. Nothing here is promoted automatically — a human holds the final call.

Follow the trail

See the evidence →1 test

the pre-registered tests, verdict, and signed provenance

View the run →

the campaign that tested this idea — Falsification campaign — 45 candidate(s), runner=modal

Grounded in

pubchem:166822065Varkaris AACR 2023 — RLY-2608 mutant-selective PI3KaCancer Discov 2024 RLY-2608

How we know it’s real

content-addressed · 517e8ac311b96f9d…updated 2026-07-07

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