SURVIVEDstx478 × PIK3CA

STX-478 (mutant-selective allosteric PI3Ka) × PIK3CA

What we’re testing

target · PIK3CAPIK3CA H1047RPIK3CA E545K

Mechanism. Mutant-selective allosteric PI3Ka inhibition (WT-sparing).

Where it stands — still standing

Survived every test the engine could run. Nothing here is proven — that's the point.

Status on the engine: evidence supported · validation-ready. Nothing here is promoted automatically — a human holds the final call.

Follow the trail

See the evidence →1 test

the pre-registered tests, verdict, and signed provenance

View the run →

the campaign that tested this idea — Falsification campaign — 45 candidate(s), runner=modal

Grounded in

pubchem:166532451Scorpion STX-478 — mutant-selective allosteric PI3Ka (WT-sparing, CNS-penetrant)

How we know it’s real

content-addressed · dc780f0c79c3686c…updated 2026-07-07

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Contribute to this idea

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