SURVIVEDzstk474 × PIK3CA

ZSTK474 (PI3K-PROTAC warhead) × PIK3CA

What we’re testing

target · PIK3CAPIK3CA

Mechanism. PI3K-degrader POI warhead: ATP-competitive class-I PI3K binder (di-morpholino-triazine benzimidazole).

Where it stands — still standing

Survived every test the engine could run. Nothing here is proven — that's the point.

Status on the engine: evidence supported · validation-ready. Nothing here is promoted automatically — a human holds the final call.

Follow the trail

See the evidence →1 test

the pre-registered tests, verdict, and signed provenance

View the run →

the campaign that tested this idea — Falsification campaign — 45 candidate(s), runner=modal

Grounded in

pubchem:11647372Jiang et al. 2018 — phthalimide-conjugated ZSTK474 PI3K degrader (S022352341830309X)

How we know it’s real

content-addressed · 305f67394d9a569d…updated 2026-07-07

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Contribute to this idea

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