We asked: Is the PIK3CA-mutant HSA subset immunosuppressed? (TME deconvolution crux)
Check what real patient tumors actually show for this axis.
Pre-registered tests, each locked to a kill-criterion before it ran. Any single one failing rules the whole idea out.
Tested as far as its inputs allowed — no verdict yet.
Readout. PIK3CA-mutant (n=5) vs WT (n=9) HSA: immunosuppression signatures are higher in the mutant stratum (0/7 significant at q<0.05). Signal: neutral.
Confidence so far: 16% — never proof.
Every result is hashed so anyone can re-derive it. Clearing these checks is necessary, not sufficient — a human still holds the final call, and nothing is auto-promoted.
See the full experiment record.
The pre-registered kill-criterion, the raw readout, and the signed provenance you can verify yourself — plus every new verdict as it lands. Drop your email and we’ll open it up.
A mailing list for early access, not a login. We’ll email you to set up real sign-in once things are polished.